الزعيم عماد عضو ذهبي
عدد الرسائل : 3450 العمر : 30 اعلام الدول : المزاج : المهن : الهواية : الاوسمة : نقاط : 1571 تاريخ التسجيل : 27/12/2008
| موضوع: Current Research In Head And Neck Cancer (Advances in Oto-Rhino-Laryngology السبت ديسمبر 27, 2008 3:43 pm | |
| urrent Research In Head And Neck Cancer (Advances in Oto-Rhino-Laryngology) By Henning Bier Publisher: S. Karger AG (Switzerland) Number Of Pages: 208 Publication Date: 2004-11-30 The development of head and neck cancer is a multistep process in which genetic as well as epigenetic alterations interfere with the regular functions of proto-oncogenes and tumor suppressor genes. In addition, carcinogenesis is promoted by the impairment of mechanisms responsible for the maintenance of genetic stability. The accumulation of crucial events such as evasion of apoptosis, lack of senescence, deregulated proliferation, invasion and metastasis, as well as neoangiogenesis eventually determines the malignant phenotype. The 16 articles of this volume span from advances in the understanding of underlying molecular pathways (conditional mouse model, folate activity, DNA repair, genomic heterogeneity, p53 family members, human papillomavirus), to preclinical and clinical studies investigating potential novel therapeutic targets (epidermal growth factor receptor, nuclear factor-kappaB, vascular endothelial growth factor, chemokine receptors, P53-based immunotherapy, virus-modi Download http://rapidshare.com/files/92848129...eck_Cancer.rar | |
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